College football odds, picks, predictions for Aug. 27, 2022: Proven computer model fading Illinois in Week 0

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More than seven months after Georgia finished off Alabama in the national title game, college football is back with a Week 0 schedule on Saturday. There are seven FBS vs. FBS matchups on the slate, and the Week 0 college football odds from Caesars Sportsbook come in all sizes. There are three double-digit favorites on the board, with Utah State (-27) listed as the largest favorite of the week.

There are some much tighter Week 0 college football lines, however, as well. North Texas vs. UTEP is listed as a pick’em, while FAU (-7) vs. Charlotte and Vanderbilt (-6.5) vs. Hawaii are single-score spreads. Which games should you be targeting during the first weekend of college football betting action? Before finalizing any college football picks for Week 0 of the 2022 season, be sure to see the latest college football predictions from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It also finished the 2021-22 college football season on a 43-31 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest college football odds for Saturday from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Aug. 27, 2022

One of the top college football picks the model is recommending for Saturday: Wyoming (+10) stays within the spread against Illinois in a 4 p.m. ET kickoff on Saturday. The Fighting Illini found success later in the 2021 season, but they still finished sub-.500 in their first season under coach Bret Bielema. Illinois also only beat one team by more than 10 points last season.

Wyoming, meanwhile, was 7-6 last season and rolled past Kent State 52-38 in the Famous Idaho Potato Bowl. The Cowboys have a lot to replace after the transfer portal hit this team hard in the offseason. But they picked up an intriguing quarterback in Andrew Peasley Jr., and the Wyoming backfield always seems to find a way to produce. Titus Swen, who ran for over 700 yards last year, could be the next big star for the Cowboys at running back.

Illinois has several new faces on offense, and SportsLine’s model is projecting that the Illini only score 26 points in this matchup. That’s enough for the Cowboys to keep it within the number as they pick up the cover almost 60% of the time in the simulations. See which other teams the model likes here.

How to make college football picks for Saturday, Aug. 27

The model has also made the call on who wins and covers in every other FBS matchup on Saturday, and it’s calling for a big favorite to get a huge scare. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which heavy favorite gets a big scare? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,600 in profit over the past six seasons, and find out.