College football odds, picks, predictions, best bets for Week 5, 2022: Proven model backing Oklahoma, Oregon

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The Week 5 college football schedule features more ranked vs. ranked matchups than any week so far this season, with five top 25 showdowns on a loaded Saturday slate. No. 7 Kentucky faces No. 14 Ole Miss early in the day, while No. 5 Clemson hosts No. 10 North Carolina State in an evening duel. Elsewhere, No. 1 Alabama is a 17-point road favorite at No. 20 Arkansas in a 3:30 p.m. ET SEC on CBS kickoff, according to the latest Week 5 college football odds at Caesars Sportsbook. The Crimson Tide opened the SEC portion of their schedule with a 55-3 win over Vanderbilt, but they struggled at Texas in their only road game so far this season.

Arkansas is looking to bounce back after losing at then-No. 23 Texas A&M last week. Should you back the Razorbacks as large home underdogs with your Week 5 college football bets? Before locking in any Week 5 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine’s advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 5 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 5

One of the college picks the model is high on in Week 5: No. 18 Oklahoma (-6.5) goes on the road and covers against TCU at noon ET on Saturday. The Sooners are coming off a narrow loss to Kansas State last week, but the model is not ready to bail on them just yet. They opened the season by beating UTEP, Kent State and Nebraska by 30-plus points each, so they have the firepower to easily cover this number.

TCU has not faced a ranked opponent so far this year and it has lost eight consecutive meetings against Oklahoma. The Sooners have covered the spread in six of their last seven wins in this series as well. They cruised to a 21-point win last season-the model expects this game to be a little trickier, but Oklahoma is still covering the spread in well over 60% of simulations.

Another one of the model’s top college football picks: No. 13 Oregon (-17) handles the double-digit spread against Stanford in Saturday’s 11 p.m. ET kickoff in Eugene. The Ducks are coming off a thrilling 44-41 come-from-behind victory over Washington State last week. Quarterback Bo Nix was the star of the show, throwing for 428 yards, three touchdowns and one interception. Nix has now accounted for at least three touchdowns in each of his last three games. For the season, Nix has thrown for 1,100 yards, 10 touchdowns and three interceptions, while also averaging 4.6 yards per carry.

Oregon is averaging 198.2 rushing yards per game this season, which ranks 29th in the nation. Stanford, meanwhile, is giving up 30.33 points per game this season. The Cardinal have also allowed 40 or more points in back-to-back Pac-12 games. SportsLine’s model is projecting the Ducks to rush for more than 200 yards against Stanford on Saturday. That helps Oregon control possession and post 40 points in this one as the Ducks cover in more than 50% of simulations. See which other teams the model likes here.

How to make college football picks for Week 5

The model has also made the call on who wins and covers in every other FBS matchup in Week 5, and it says a top-10 favorite will go down hard in one of the week’s biggest games. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which top-10 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned more than $3,100 in profit over the past six-plus seasons, and find out.