Clemson vs. North Carolina State prediction, odds: 2022 Week 5 college football picks from proven model

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The 10th-ranked North Carolina State Wolfpack open their Atlantic Coast Conference slate on Saturday when they take on the fifth-ranked Clemson Tigers. Defense has been key for the Wolfpack (4-0), who are allowing just 11.9 points per game, tops in the conference and eighth in the FBS. The Tigers (4-0), who are 2-0 in ACC play, are allowing 21.8. Clemson enters the game with a 36-game home winning streak, dating back to 2016.

Kickoff from Memorial Stadium in Clemson, S.C., is set for 7:30 p.m. ET. North Carolina State averages 411 yards per game in 2022, while Clemson averages 458.5. The Tigers are 7-point favorites in the latest North Carolina State vs. Clemson odds from Caesars Sportsbook, while the over/under for total points scored is 45.5. Before making any Clemson vs. NC State picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on NC State vs. Clemson and just locked in its picks and CFB predictions. You can visit SportsLine now to see the model’s picks. Here are the college football odds and betting lines for Clemson vs. NC State:

  • North Carolina State vs. Clemson spread: Clemson -7 
  • North Carolina State vs. Clemson over/under: 45.5 points 
  • North Carolina State vs. Clemson money line: North Carolina State +215, Clemson -267 
  • NCST: The Wolfpack are 5-2 against the spread in their last seven games against a team with a winning record 
  • CLEM: The Tigers are 20-9 ATS in their last 29 games after scoring more than 40 points in their previous game 
  • North Carolina State vs. Clemson picks: See picks here

Featured Game | Clemson Tigers vs. NC State Wolfpack

Why Clemson can cover

Sophomore Will Shipley has emerged as a difference-maker for the Tigers. Shipley recorded multiple rushing touchdowns in each of Clemson’s first three games and now has multiple rushing TDs in half of his 14 career games played. He became the first Clemson player in single-game records back to 1950 to score multiple rushing touchdowns in each of the first three games of a season. Shipley is already one of six Clemson players since 2000 to record at least seven career games with multiple rushing touchdowns. With seven rushing touchdowns, Shipley leads the ACC and ranks tied for third nationally.

DJ Uiagalelei enters this week’s game with a 15-4 career record as the Tigers’ starting quarterback, going 1-1 in 2020, 10-3 in 2021 and 4-0 so far this season. With the overtime win at Wake Forest last week, Uiagalelei became only the 17th Clemson player since World War II to earn 15 career victories as the Tigers’ starting quarterback. He has thrown for 1,033 yards and 10 touchdowns in 2022. He has also rushed 41 times for 169 yards (4.1) and one touchdown.

Why North Carolina State can cover 

Redshirt junior quarterback Devin Leary has been a big part of the Wolfpack’s success. Over the past two seasons, he has posted a 16-3 record as N.C. State’s starting quarterback. In 24 starts in his career, he has thrown 60 touchdowns, tied for fourth-best in school history and just three away from entering the top three on the list. Last season, Leary threw a school-record 35 touchdowns, including a league-leading 27 against ACC opponents.

Defensively, the Wolfpack have done a good job of taking away the football. North Carolina State recorded at least two interceptions in each of the first three games of the season. No N.C. State team had accomplished a streak of three consecutive games with two or more interceptions since the final three games of the 2011 season. The Wolfpack’s seven interceptions in the first three games this year tied as the fourth-most all-time in school history. The top three for interceptions were in 1998 (10), 1991 (10) and 1960 (eight).

How to make North Carolina State vs. Clemson picks

SportsLine’s model is leaning Over on the total, projecting 54 combined points. It has also generated an against-the-spread pick that cashes in more than 60% of simulations. You can only get the model’s pick at SportsLine

So who wins North Carolina State vs. Clemson? And which side of the spread cashes in more than 60% of simulations? Visit SportsLine now to see which side of the North Carolina State vs. Clemson spread to jump on, all from the advanced model that finished the past six-plus years up more than $3,100 on its FBS college football picks, and find out.



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