College football odds, picks, predictions for Aug. 27, 2022: Advanced computer model fading Illinois in Week 0

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After nearly an eight month offseason, the 2022 college football season is finally upon us, beginning on Saturday, Aug. 27. The week’s slate of 11 FBS games has been coined Week 0 and it features six Power-5 teams in action. The Week 0 college football schedule is highlighted by Nebraska vs. Northwestern in Ireland, which is the week’s only matchup with two Power-5 teams. The Cornhuskers, who are coming off a 3-9 season, are 13-point favorites in the latest Week 0 college football odds per Caesars Sportsbook.

Other matchups include Illinois vs. Wyoming, Florida State vs. Duquesne and Vanderbilt vs. Hawaii. Also, Connecticut begins its first season under coach Jim Mora, and its game versus Utah State has an over/under of 60.5, which is the highest among the Week 0 college football lines. Will the points pile up to hit the Over in that matchup, and which side should you lean towards in the Big Ten contest? Before finalizing any college football picks for Week 0 of the 2022 season, be sure to see the latest college football predictions from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It also finished the 2021-22 college football season on a 43-31 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest college football odds for Saturday from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Aug. 27, 2022

One of the top college football picks the model is recommending for Saturday: Wyoming (+10) easily stays within the spread on the road at Illinois in a 4 p.m. ET matchup. Wyoming returns one of the top running backs in the Mountain West in Titus Swen, whose 5.9 rushing average ranked second in the conference last season. He piled up 169 yards and two touchdowns against an 11-win Utah State team last year and now gets to be the Cowboys’ featured back after starter Xazavian Valladay transferred to Arizona State.

In recent years, Wyoming has developed a knack for playing better in non-conference games than within the Mountain West as it has a 9-1 straight-up record over its last 10 non-conference contests. Meanwhile, Illinois enters the 2022 college football season with 10 straight losing seasons after going 5-7 under Bret Bielema last year. The Fighting Illini fielded one of the worst offenses in all of college football, ranking 116th out of 130 FBS teams in points (20.2 per game).

On the other hand, Wyoming has had one of the stingiest defenses in the nation in recent years. Over each of the past five seasons, the Cowboys have finished among the top third of all defenses in points allowed per game. Wyoming held seven opponents to two touchdowns or fewer in 2021, and it could feast off new Illinois QB Tommy DeVito, who had more interceptions than touchdowns in limited playing time last year with Syracuse.

SportsLine’s model says Wyoming defense does enough to keep it within the number as it has the Cowboys covering in almost 60% of simulations. See which other teams the model likes here.

How to make college football picks for Saturday, Aug. 27

The model has also made the call on who wins and covers in every other FBS matchup on Saturday, and it’s calling for a big favorite to get a huge scare. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which heavy favorite gets a big scare? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,600 in profit over the past six seasons, and find out.