College football odds, picks, predictions for Week 3, 2022: Proven computer model likes Ole Miss, Notre Dame

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There might not be any blockbuster matchups on the Week 3 college football schedule, but there are still a pair of ranked vs. ranked contests on Saturday. No. 12 BYU will be looking to back up its big win over Baylor when it travels to No. 25 Oregon, while No. 24 Texas A&M is hosting No. 13 Miami in the nightcap. Oregon is a 3.5-point favorite in the latest Week 3 college football odds at Caesars Sportsbook, and Texas A&M is a 5.5-point favorite against Miami. Should you be targeting these matchups with your Week 3 college football bets?

Some of the other enticing Week 3 college football spreads include No. 11 Michigan State as a 3.5-point road underdog at unranked Washington, and No. 22 Penn State at -3 on the road against Auburn. Which Week 3 college football lines hold the most value? Before locking in any Week 3 college football picks for those games or others, be sure to see the latest college football predictions from SportsLine’s advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It enters Week 3 of the 2022 college football season on a 50-41 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 3 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 3

One of the college picks the model is high on in Week 3: The Notre Dame Fighting Irish cover the 11-point spread against the Cal Golden Bears at home in a 2:30 p.m. ET matchup on Saturday. Notre Dame held a 10-7 lead at No. 2 Ohio State in the opening week of the season, but that feels like a distant memory after the Fighting Irish lost that game and then suffered a shocking upset loss to Marshall last week. They were never able to get going against the Thundering Herd, but SportsLine’s model expects them to come out fully focused on beating Cal this week.

Quarterback Tyler Buchner had season-ending shoulder surgery, so Drew Pyne will start at quarterback for Notre Dame. He led a late touchdown drive against Marshall last week, but it was not enough in the 26-21 setback. Cal comes into this game undefeated, despite struggling at home against UC Davis and UNLV.

Notre Dame was expected to be a College Football Playoff contender this season, while Cal was picked to finish near the bottom of the Pac-12. SportsLine’s model believes the loss to Marshall has created value on the Fighting Irish as 11-point favorites this week, as they are covering the spread in more than 50% of the latest simulations.

Another one of the model’s college football picks: The No. 20 Ole Miss Rebels cover the 17-point spread against the Georgia Tech Yellow Jackets in Atlanta at 3:30 p.m. ET on Saturday. Ole Miss might have lost its star quarterback to the NFL, but the Rebels have looked excellent during the first two weeks of the season. They picked up a 28-10 win over Troy in Week 1 before blowing out Central Arkansas in a 59-3 final last week.

Sophomore quarterback Jaxson Dart has completed 66.7% of his passes so far this season, and he has shown some mobility with six carries for 45 yards. Georgia Tech did not fare well against a ranked opponent two weeks ago, getting dominated in the second half of a 41-10 loss to Clemson. The Yellow Jackets bounced back with a 35-17 win over Western Carolina, but they failed to cover the 24-point spread.

SportsLine’s model expects Dart to torch Georgia Tech’s defense for 327 yards and two touchdowns, while running backs Zach Evans and Quinshon Judkins are projected to tally more than 180 combined rushing yards. Their success is one of the primary reasons why Ole Miss is covering the spread in almost 70% of simulations. See which other teams the model likes here.

How to make college football picks for Week 3

The model has also made the call on who wins and covers in every other FBS matchup in Week 3, and it’s calling for multiple outright upsets. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which favorites will go down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,400 in profit over the past six-plus seasons, and find out.